Catalogue

Background
Human hematopoetic malignancies are often characterized by gene rearrangements that deregulate gene expression. Antibodies to human bcl-2 (B cell leukemia/lymphoma 2) are directed against the gene isolated at the chromosomal breakpoint t(14;18) Bcl-2 which suppress programmed cell death (apoptosis) and appears to be modulated by association with bax, a cell death promoter.

Synonyms: hbcl2, sheep anti human bcl 2, bcl-2

Source
Sheep were immunized with full length recombinant bcl-2 protein

Product
Provided as solution in phosphate buffered saline with 0.08% sodium azide

Product Form: Unconjugated

Purification Method: Ammonium Sulfate Precipitation

Concentration: See vial for concentration

Applications
Western Blots at 1:5000, Immunoprecipitation – Empirical, Immunofluorescence 1:5000.

Functional Analysis: Western Blotting

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References
1. Chida, Y., et al. 'The hepatic sympathetic nerve plays a critical role in preventing Fas induced liver injury in mice.' Gut 2005, 54, 994-1002 (Product specific)

Protein Reference(s)

Database Name: UniProt

Accession Number: P10415

Safety Datasheet(s) for this product: