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New parent company unites multiple antibody-centric brands to deliver unique antibody solutions ...Read More

SCICONS’ mouse anti double-stranded RNA antibody (clone J2) was used in crucial research to identify potent therapeutic agents to impede SARS-CoV-2 viral entry into host cells. ...Read More

Nordic-MUbio announces the acquisition of Scicons who provide highly cited monoclonal antibodies used by researchers worldwide as a reliable tool for dsRNA detection. The team at Nordic-MUBio is committed to making sure that the SCICONS product range will be managed correctly and that all SCICONS and Nordic MUbio customers will be given exceptional customer service, deep expertise and an environment you all want to be part of. ...Read More

Cancer is an incredibly complex disease involving the aberrant expression and function of many different proteins. p53 is one of the most widely studied examples, with approximately 50% of human cancers known to carry mutations in the gene (TP53) encoding this essential nuclear transcription factor1. Under normal conditions, p53 works as a tumor suppressor to enable cells to respond to ...Read More

0566P is a new addition to the Exalpha Biologicals portfolio, complementing our existing range of high-quality mouse monoclonal antibodies to Neural Cell Adhesion Molecule (NCAM/CD56). Produced by cloning the sequence of our popular, literature-cited antibody, 561 (clone C5.9), 0566P has been given clone number C5.9 E1. In partnership with LSBio, 0566P has been validated for use in flow cytometry, immunocytochemistry, ...Read More

At Exalpha Biologicals our aim is to make continuous improvements while providing the best quality and value for our customers. As part of this mission, we are proud to relaunch our updated BrdU Immunohistochemistry Kit (product code #X1545K.1) produced using more animal-friendly manufacturing processes. Bromodeoxyuridine (BrdU) is a thymidine analog which is selectively incorporated into the DNA of proliferating cells, ...Read More

Want to develop a COVID-19 diagnostic test? Exalpha Biological’s range of mouse anti-human immunoglobulin (Ig) antibodies are ideal for diagnostic kit development. The mouse monoclonal antibodies, against a range of human Ig heavy and light chains, are suitable for the detection of antibody present in human serum, other body fluids, cells and tissue. Diagnostic enzyme-linked immunosorbent assays (ELISA) utilize antibodies ...Read More

Exalpha Biologicals’ Biologo antibodies Included within Exalpha Biologicals’ product offering, Biologo branded reagents are widely literature-cited and span multiple research areas. Most prominent among these are antibodies developed to support the study of advanced glycation end-products (AGE) and cancer, and antibodies raised against collagens from various species. Advanced glycation end products Advanced glycation end-products are a diverse group of proteins ...Read More

Recombinant Versions of a Popular Vimentin Antibody Provide Researchers With Greater Flexibility Vimentin is a 57kDa class III intermediate filament protein, found mainly in mesenchymal cells. Like other forms of intermediate filament protein, it commonly colocalizes with microtubules to stabilize cytoskeletal interactions and provide cellular strength and support. Vimentin over-expression is a hallmark of many cancers, correlating with increased tumor ...Read More

MUB0910P – improved purity enhances data quality Our mouse anti-integrin alpha 5 antibody (CD49e), MUB0910P, is just one of many high-quality integrin antibodies within our portfolio. Produced by fusing mouse myeloma cells with spleen cells from BALB/C mice immunized with U937 histiocytic lymphoma cells, this clone (NKI-SAM-1) has been widely literature cited for integrin research. Now, as a result of ...Read More

To ensure we continually deliver on our objective of providing research products that answer real scientific needs, we have included within our portfolio a range of antibodies from ELTI. This includes antibodies raised in chicken hosts against targets such as the herbicide glyphosate, the insecticide fenitrothion, and the pesticide chlorpyrifos, in addition to rabbit antibodies against drugs such as clofibrate, ...Read More

The popular human epithelial cell marker antibody is specific for a 34 kDa epithelium-specific membrane glycoprotein. It labels the majority epithelial cells and epithelium derived tumours, reacting strongly with all carcinoma derived from the intestinal tract, stomach, pancreas, breast, lung, kidney, prostate, ovary and thyroid gland (1). The ability of HEA125 to distinguish between carcinoma and non-carcinoma has significant clinical ...Read More

A strategy combining the use of FIX&PERM® for the intracellular detection of the cell cycle marker Ki-67 and 10 colour flow cytometry of cell surface markers was used to determine reference values for the proliferative activity of hematopoietic cells in normal bone marrow. Hematologic malignancies such as leukaemia and lymphomas are forms of cancer that begin in the cells of ...Read More

Eggcellent Antibodies Utilising Gallus’ eggspertise, Exalpha Biologicals is now able to offer a greatly expanded range of antibodies generated in chicken. Why use chickens to produce antibodies? Polyclonal antibodies generated in chickens, offer many advantages over polyclonal antibodies traditionally produced in mammals such as rabbits, goats and sheep. Chickens (Gallus domesticus) produce immunoglobulin not only in their ...Read More

Exalpha Biologicals, Inc. Announces Acquisition of Leading Producer of Egg-Derived Antibodies Gallus Immunotech Inc. Continues expansion of its range of Antibodies and Reagents that answer real needs Shirley, Massachusetts, USA – June 6th, 2018 – Exalpha Biologicals, Inc., founded over 20 years ago and dedicated to accelerating the pace of discovery in the life science arena announces the acquisition ...Read More

Clinical IHC Markers Immunohistochemistry (IHC) is a technique which is used to study the tissue distribution of a defined target. It relies on antibodies to detect specific proteins in a sample of tissue which has been paraffin embedded or frozen and can provide a wealth of data regarding protein localization and relative levels of expression. In a clinical laboratory setting ...Read More

Veterinary Antibodies Veterinary research is essential to understanding a wide range of pathological conditions in veterinary species. The research undertaken supports a broad range of veterinary disciplines including clinical veterinary medicine, animal husbandry, infectious disease dynamics, zoonotics and comparative medicine. In addition, many diseases affecting companion animals, livestock, wild animals and birds have an impact on global economics, and ongoing ...Read More

What are GPCRs? G-Protein Coupled Receptors (GPCRs) represent the largest and most diverse family of transmembrane receptors in the human genome, and have been extensively targeted by the pharmaceutical industry in the development of therapeutics. They are involved in a huge array of functions and, as their name suggests, interact with G-proteins (specialized proteins capable of binding GTP and GDP) ...Read More

Background Secreted Protein Acid Rich in Cysteine (SPARC), also known as ON (osteonectin) and BM-40 (basement-membrane protein 40), is a prototypic member of the SPARC family of proteins, a diverse group of proteins that each have an acidic domain, a follistatin-like domain and an extracellular calcium binding E-F hand motif. SPARC is a 34-35kD non-structural matricellular protein that is primarily ...Read More

Link between p34(cdc2) and Punctate Palmoplantar Keratoderma. p34(cdc2) is a kinase which is an essential nuclear protein for mitosis in human cells. During the prophase/metaphase transition the inactive phosphorylated form of p34(cdc2) is dephosphorylated to yield the active form of the protein. Recent data published in Nature Genetics (14 October 2012) from Pohler et al link a heterozygous loss-of-function mutation ...Read More

Although only a fraction of genes in the human genome have a direct association with the induction and development of cancer, two broad gene classes – proto-oncogenes and tumor suppressor genes – have demonstrated a clear link to progression of the disease. These genes encode various proteins involved in regulating cell growth and proliferation, and while gain-of-function mutations in proto-oncogenes ...Read More

M13 Bacteriophage Background Discovered in 1963, M13 bacteriophage was first isolated from Escherichia coli bacteria. M13 is a single stranded DNA virus that belongs to the Inoviridae family of filamentous bacteriophages, which infect gram- negative bacteria. It is a member of the Ff (F-specific filamentous phage) class of phages and is one of the smallest filamentous bacteriophages known. M13 phage ...Read More

High quality reagents for Edg research The Edg GPCRs have been extensively studied due to the role which they play in the regulation of fundamental cellular processes including proliferation, migration and differentiation. Such research is dependent on the use of high quality reagents, and Exalpha Biologicals offers a comprehensive range of antibodies (monoclonal and polyclonal), blocking peptides, membrane preparations and ...Read More

The endothelial cell differentiation gene (Edg) family of G-protein coupled receptors (GPCR) function as receptors for Lysophosphatidic acid (LPA) and structurally related sphingosine-1-phosphate (S1P). LPA and S1P are predominantly released by activated platelets and are present in blood plasma and serum, mainly bound to albumin and lipoprotein. Both LPA and S1P mediate similar biological cell responses including cell proliferation, migration, ...Read More

BrdU 5′-bromo-2′-deoxyuridine (BrdU) is a synthetic analogue of the nucleoside thymidine, in which the 5-methyl group is substituted by bromine. It is commonly used for the detection of proliferating cells via its incorporation into newly synthesized DNA; replicating cells can subsequently be identified through the use of anti-BrdU antibodies. BrdU has been used for decades and has extremely wide utility. ...Read More

Recent work by Rachael Lallensack published in Nature, 18 September 2017 has shed light on the way in which the intricate patterns on butterfly wings form. It had been thought that the process of generating the beautiful and complex patterns on butterfly wings might be due to the action of a multitude of different genes. Recent studies, however, seem to ...Read More