Catalogue

Background
In neurons voltage-dependent potassium channels are key determinants of the resting membrane potential and of membrane excitability, conditioning the frequency, and shape of action potential (1). Potassium channels are encoded by numerous genes whose products can be classified into distinct subfamilies. The most distinctively characterized is that of the Kv1 shaker class (2).

Synonyms: Rabbit anti Kv1.4 Potassium Channel

Source
Rabbits were immunized with a peptide derived from rat Kv1.4 potassium channel protein, conjugated to KLH

Product
Provided as solution in phosphate buffered saline with 0.08% sodium azide

Product Form: Unconjugated

Purification Method: Ammonium Sulfate Precipitation

Concentration: See vial for concentration

Specificity

Species Reactivity: The rabbit anti kv 1.4 ptassium channel antibody recognizes a 90 kDa protein by western blot on rat hippocampal membranes and a protein of 76 kDa in lysates of HEK293 cells (3).

Applications
Applications: 1- 10 ug/ml for western blot analysis, immunofluorescence, immunoprecipitation.

Functional Analysis: Western Blotting

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature.

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References
1) Miller C. Science 1991: 252;1092-1096 2) Chandy K.G. et al. Handbook of receptors and channels. CRC Press 1995; 1-71. 3) Jugloff J.G.M. et al. J. Biol. Chem. 2000: 275; 1357-1364.

Protein Reference(s)

Database Name: UniProt

Accession Number: P15385

Species Accession: Rat

Safety Datasheet(s) for this product: