Catalogue

Background
The function of this binding protein is not fully known. It is known to interact with the S100P and colocalizes with S100P in the nucleus. S100P may stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).

Synonyms: S100PBP

Source

Immunogen: Synthetic peptide derived from human S100P-binding protein.

Product

Product Form: Affinity Purified

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purification Method: Antigen Immunoaffiinity Purification

Concentration: See vial for concentration

Applications
Optimal concentration should be evaluated by serial dilutions.

Functional Analysis: Western Blotting

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References
1. Dowen, S.E., et al. ‘Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer.’ Am. J. Pathol., 166, 81-92 (2005) 2. Deng, H., et al. ‘Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens.’ Am. J. Clin. Pathol., 129, 81-88 (2008)

Protein Reference(s)

Database Name: SwissProt

Accession Number: Q96BU1

Species Accession: Human

Safety Datasheet(s) for this product: