Catalogue

Background
Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1c gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). Calcium channels containing the alpha-1c subunit play an important role in excitation-contraction coupling in the heart.

Synonyms: RBC-II; Cav1.2; Calcium channel ( L type) voltage gated 1c; Cacna1c

Source

Immunogen: Synthetic peptide derived from the rat alpha1C calcium channel conjugated to KLH

Product

Product Form: Affinity Purified

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purification Method: Antigen Immunoaffiinity Purification

Concentration: See vial for concentration

Applications
Antibody can be used for Western blotting (1:400 dilution). Optimal concentration should be evaluated by serial dilutions.

Functional Analysis: Western Blotting

Positive Control: Normal human kidney tissue

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References
1. Snutch,T.P et.al 'Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian' CNS Neuron 7 (1), 45-57 (1991) 2. Hansen, P.B. et.al 'Differential expression of T- and L-type voltage-dependent calcium channels in renal resistance vessels.' Circ Res;89(7):630-8 (2001) 3. Chung,Y.H. et.al 'Differential alterations in the distribution of voltage-gated calcium channels in aged rat cerebellum.' Brain Res 8;903(1-2):247-52.(2001)

Safety Datasheet(s) for this product: