Catalogue

Background
KLF14 is a member of the KrŸppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGF RII (the type II receptor for TGF ). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression.

Synonyms: Krueppel-like factor 14, BTE-binding protein 5

Source

Immunogen: Synthetic peptide derived from the human KLF14 protein

Product

Product Form: Affinity Purified

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purification Method: Antigen Immunoaffiinity Purification

Concentration: See vial for concentration

Applications
Antibody can be used for immunohistochemistry (2-4 µg/ml) and Western blotting (1-2 µg/ml). Optimal concentration should be evaluated by serial dilutions.

Functional Analysis: Western Blotting

Positive Control: Human tonsil

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References
1. Truty, M.J., et al. ‘Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling.’ J. Biol. Chem., 284, 6291-6300 (2009) 2. Swamynathan, S.K. ‘Krüppel-like factors: three fingers in control.’ Hum. Genomics, 4, 263-270 (2010) 3. Parker-Katiraee, L., et al. ‘Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution.’ PLoS Genet., 3, e65, (2007)

Protein Reference(s)

Database Name: SwissProt

Accession Number: Q8TD94

Species Accession: Human

Safety Datasheet(s) for this product: