Catalogue

Background
P107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors.

Synonyms: p107; Retinoblastoma-like protein 1; PRB1; 107 kda retinoblastoma-associated protein

Source
The immunogen used to immunize the mice was a recombinant GST protein coupled to the N-terminus of p107.

Product
KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107kDa.

Product Form: Unconjugated

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purification Method: Protein A/G Chromatography

Concentration: See vial for concentration

Applications
Western Blots at 1:1000

Functional Analysis: Western Blot

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

Protein Reference(s)

Database Name: UniProt

Accession Number: P28749 (Human) Q64701 (Mouse)

Species Accession: Human

Safety Datasheet(s) for this product: